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  • Celiac disease: Exploring four myths

    Celiac disease: Exploring four myths

    Gluten-free bread & bagels with 12 appetizing toppings like avocado & olives, hummus & chickpeas, sliced hardboiled eggs & greens; concept is celiac disease

    Celiac disease is a digestive and immune disorder that can keep the body from absorbing necessary nutrients. “Our conception and awareness of celiac disease has evolved over the past few decades, but there are still aspects that remain poorly understood,” says Dr. Ciaran Kelly, medical director of the Celiac Center at Beth Israel Deaconess Medical Center and professor of medicine at Harvard Medical School.

    Perhaps not surprisingly, misconceptions are widespread among the general public. One example? Many people assume that everyone who has celiac disease is plagued by abdominal pain, bloating, or diarrhea. But actually, many adults newly diagnosed with this inherited gluten intolerance don’t have these symptoms.

    What’s more, gluten — the sticky protein found in grains such as wheat, barley, and rye — can cause gastrointestinal distress and other symptoms in people who don’t have celiac disease. Read on for a deeper dive into four myths and facts about celiac disease and related digestive conditions.

    Myth # 1: Celiac disease is usually diagnosed at a young age

    Not typically. While celiac disease can develop any time after a baby’s first exposure to gluten, it’s usually diagnosed much later in life. According to the National Celiac Association, the average age of diagnosis is between 46 and 56. Around 25% of people are diagnosed after age 60.

    Celiac disease is slightly more common in women and among people with other autoimmune conditions, including type 1 diabetes, Hashimoto’s thyroiditis (a common cause of low thyroid levels), and dermatitis herpetiformis (a rare condition marked by an itchy, blistering rash).

    “We don’t know why some people go from being susceptible to actually having celiac disease,” says Dr. Kelly. The prevailing theory is that some sort of physical or emotional stress — such as a viral infection, surgery, or anxiety from a stressful life event — may “flip the switch” and cause the disease to appear, he says. “Increasing numbers of people are being diagnosed at midlife and older, often after they’re found to have conditions such as anemia or osteoporosis caused by nutrient deficiencies,” says Dr. Kelly.

    Myth #2: Celiac disease only affects the gut

    When people have celiac disease, eating gluten triggers an immune system attack that can ravage the lining of the small intestine. A healthy small intestine is lined with fingerlike projections, called villi, that absorb nutrients. In celiac disease, the immune system attacks the villi, causing them to flatten and become inflamed — and thus unable to adequately absorb nutrients.

    While gastrointestinal problems can occur, they aren’t always present. In fact, celiac disease can present with many different symptoms that affect the nervous, endocrine, and skeletal systems. A few examples are brain fog, changes in menstrual periods, or muscle and joint pain.

    Myth # 3: Celiac disease versus gluten intolerance

    If you feel sick after eating gluten, you probably have celiac disease, right? Actually, that may not be true. Some people have non-celiac gluten sensitivity (also called gluten intolerance), which can cause uncomfortable digestive symptoms after eating gluten. But gluten intolerance differs from celiac disease.

    • Celiac disease is diagnosed with blood tests that look for specific antibodies. If antibodies are present, a definitive diagnosis requires an intestinal biopsy to look for signs of damage that characterize the condition.
    • Non-celiac gluten sensitivity does not trigger antibodies or cause intestinal damage. Yet some people with this problem say they also experience brain fog, trouble concentrating, muscle aches and pain, and fatigue after eating gluten-containing foods.

    “Non-celiac gluten sensitivity appears to be a real phenomenon, but it’s not well defined,” says Dr. Kelly. It’s unclear whether people experiencing it are intolerant to gluten or to something else in gluten-containing foods.

    • One possibility is sugarlike molecules known as FODMAPs, which are found in many foods — including wheat. Short for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, gas and bloating can occur when gut bacteria feed on FODMAPs.
    • Another possibility is an allergy to wheat, which can cause symptoms such as swelling, itching, or irritation of the mouth and throat after eating wheat. Other symptoms include a skin rash, stuffy nose, and headache, as well as cramps, nausea, and vomiting. Some people may develop a life-threating allergic reaction known as anaphylaxis.

    Myth #4: A gluten-free diet always relieves the symptoms and signs of celiac disease

    The sole treatment for celiac disease — adopting a diet that avoids all gluten-containing foods — doesn’t always help. This problem is known as nonresponsive celiac disease.

    “About 20% of people with celiac disease have ongoing symptoms, despite their best efforts to stick to a gluten-free diet,” says Dr. Kelly. Others have intermittent signs and symptoms, particularly when they are accidentally exposed to gluten. Accidental exposures often happen when people eat prepared or restaurant foods that claim to be gluten-free but are not. Cross contamination with gluten-containing foods is another potential route.

    Potential solutions to nonresponsive celiac disease are being studied. Three promising approaches are:

    • Enzymes that break down gluten, which people could take alongside gluten-containing foods. “It’s a similar concept to the lactase pills taken by people who are lactose intolerant to help them digest dairy products,” says Dr. Kelly.
    • Dampening the immune response to gluten by inhibiting an enzyme called tissue transglutaminase that makes gluten more potent as an antigen.
    • Reprogramming the immune response to prevent the body from reacting to gluten.

    About the Author

    photo of Julie Corliss

    Julie Corliss, Executive Editor, Harvard Heart Letter

    Julie Corliss is the executive editor of the Harvard Heart Letter. Before working at Harvard, she was a medical writer and editor at HealthNews, a consumer newsletter affiliated with The New England Journal of Medicine. She … See Full Bio View all posts by Julie Corliss

    About the Reviewer

    photo of Howard E. LeWine, MD

    Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Howard LeWine is a practicing internist at Brigham and Women’s Hospital in Boston, Chief Medical Editor at Harvard Health Publishing, and editor in chief of Harvard Men’s Health Watch. See Full Bio View all posts by Howard E. LeWine, MD Share

  • Can saw palmetto treat an enlarged prostate?

    Can saw palmetto treat an enlarged prostate?

    Close-up of ripe berries on a branch of a saw palmetto tree; the berries are used in the making of a dietary supplement.

    Marketed as a natural remedy for an enlarged prostate, saw palmetto is a top-selling dietary supplement. It’s extracted from berries that grow on saw palmetto palm trees, which are native to the southeastern United States.

    By one estimate, more than a third of all US adults who take supplements use saw palmetto specifically. Some evidence suggests that saw palmetto has anti-inflammatory properties, and its use as folk medicine dates back over a century.

    But experts at Harvard say men should view its supposed benefits for prostate health skeptically. “Saw palmetto is unlikely to harm you, but it probably won’t provide any major benefits either,” says Dr. Heidi Rayala, an assistant professor of urology at Harvard Medical School and Beth Israel Deaconess Medical Center.

    BPH and the potential effect of saw palmetto

    It’s common for men to develop an enlarged prostate, or benign prostatic hyperplasia (BPH), when they get older. BPH impedes urinary flow through the urethra, causing obstructive symptoms that can worsen with time.

    Just how saw palmetto might act on the prostate to improve symptoms isn’t entirely clear, however. Some evidence suggest it mimics the effects of certain drugs used for treating BPH, including 5-alpha reductase inhibitors such as finasteride (Proscar), which shrink the prostate gland.

    In the US, no herbal supplement is approved as BPH treatment. The American Urological Association cautions that studies backing saw palmetto for treating enlarged prostates have numerous flaws, including short durations and a lack of placebo controls. Most of the supporting evidence comes from small studies paid for by companies that sell dietary supplements.

    What do randomized clinical trials show?

    The best-conducted research shows no benefits from saw palmetto for BPH. During one study, 225 men with moderate to severe BPH were treated with either a placebo or 160 milligrams (mg) of saw palmetto, taken twice daily for a year. The investigators detected no difference in outcomes, but they also acknowledged that doses tested in the study may have been too low to produce measurable effects.

    So, during a larger subsequent study, researchers tested higher doses of saw palmetto ranging up to 320 mg given three times a day. Nearly 370 men ages 45 and older were randomized to treatment or placebo groups. After year and a half, men in both groups reported feeling either no worse or a little better. Remarkably, 40% of the placebo-treated men said symptoms had improved, suggesting the simple act of taking a pill could have something to do with the supplement’s perceived benefits.

    Dr. Michael Barry, a professor of medicine at Harvard Medical School, led the study. He urges men to consult with their doctors before trying saw palmetto, mainly to rule out other potential causes of urinary obstruction, which can include bladder or prostate cancer. And saw palmetto may interfere with the blood’s clotting ability, making it risky for men who take blood thinners.

    Recent results and comments

    The latest evidence on saw palmetto and BPH comes from a Cochrane Review of 27 placebo-controlled studies enrolling a combined 4,656 participants. Results published in 2024 showed no improvement in urinary symptoms or quality of life from taking saw palmetto (alone or with other herbal supplements) over durations ranging up to 17 months.

    “If the ingredients in these herbal products worked well for urinary symptoms, drug companies would have already had them approved by the FDA as a medicine that insurance companies would have to cover,” Dr. Rayala said. “It’s okay to take them, but just be cautious about spending too much of your own money on these alternatives.”

    “It is easy to understand why so many find taking a naturally occurring supplement for treating urinary difficulties in middle age appealing,” said Dr. Marc Garnick, the Gorman Brothers Professor of Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, and editor in chief of the Harvard Medical School Guide to Prostate Diseases. “However, evidence of effectiveness with saw palmetto is lacking, and its use for BPH and other common urinary symptoms without a full evaluation of the potential cause should be discouraged.”

    About the Author

    photo of C.W. Schmidt

    C.W. Schmidt, Editor, Harvard Medical School Annual Report on Prostate Diseases

    C.W. Schmidt is an award-winning freelance science writer based in Portland, Maine. In addition to writing for Harvard Health Publishing, he has written for Science magazine, the Journal of the National Cancer Institute, Environmental Health Perspectives, … See Full Bio View all posts by C.W. Schmidt

    About the Reviewer

    photo of Marc B. Garnick, MD

    Marc B. Garnick, MD, Editor in Chief, Harvard Medical School Annual Report on Prostate Diseases; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Marc B. Garnick is an internationally renowned expert in medical oncology and urologic cancer. A clinical professor of medicine at Harvard Medical School, he also maintains an active clinical practice at Beth Israel Deaconess Medical … See Full Bio View all posts by Marc B. Garnick, MD Share

  • Think your child has ADHD? What your pediatrician can do

    Think your child has ADHD? What your pediatrician can do

    A green blackboard with the letters A D H D in chalk, with hand-drawn, squiggly arrows in multiple colors of chalk pointing outward in all directions from the letters.

    ADHD, or attention deficit hyperactivity disorder, is the most common neurobehavioral disorder of childhood. It affects approximately 7% to 8% of all children and youth in the US. As the American Academy of Pediatrics (AAP) points out in their clinical practice guideline for ADHD, that’s more than the mental health system can handle, which means that pediatricians need to step up and help out.

    So, if your child is having problems with attention, focus, hyperactivity, impulsivity, or some combination of those, and is at least 4 years old, your first step should be an appointment with your child’s primary care doctor.

    What steps will your pediatrician take?

    According to the AAP, here’s what your doctor should do:

    Take a history. Your doctor should ask you lots of questions about what is going on. Be ready to give details and examples.

    Ask you to fill out a questionnaire about your child. Your doctor should also give you a questionnaire to give to your child’s teacher or guidance counselor.

    A diagnosis of ADHD is made only if a child has symptoms that are

    • present in more than one setting: For most children, that would be both home and school. If symptoms are only present in one setting, it’s less likely to be ADHD and more likely to be related to that setting. For example, a child who only has problems at school may have a learning disability.
    • causing a problem in both of those settings: If a child is active and/or easily distracted, but is getting good grades, isn’t causing problems in class, and has good relationships in school and at home, there is not a problem. It bears watching, but it could be just personality or temperament.

    There are ADHD rating scales that have been studied and shown to be reliable, such as the Vanderbilt and the Conners assessments. These scales can be very helpful, not just in making diagnoses, but also in following the progress of a child over time.

    Screen your child for other problems. There are problems that can mimic ADHD, such as learning disabilities, depression, or even hearing problems. Additionally, children who have ADHD can also have learning disabilities, depression, or substance use. It’s important to ask enough questions and get enough information to be sure.

    Discussing treatment options for ADHD

    If a diagnosis of ADHD is made, your pediatrician should discuss treatment options with you.

    • For 4- and 5-year-olds: The best place to begin is really with parent training on managing behavior, and getting support in the classroom. Medications should only be considered in this age group if those interventions don’t help, and the child’s symptoms are causing significant problems.
    • For 6- to 12-year-olds: Along with parent training and behavioral support, medications can be very helpful. Primary care providers can prescribe one of the FDA-approved medications for ADHD (stimulants, atomoxetine, guanfacine, or clonidine). In this age group, formal classroom support in the form of an Individualized Education Program (IEP) or a 504 plan should be in place.
    • For 12- to 18-year-olds: The same school programs and behavioral health support should be in place. Medications can be helpful, but teens should be part of that decision process; shared decision-making is an important part of caring for teens, and for getting them ready to take on their own care when they become adults.

    Follow-up care for a child with ADHD

    Your pediatrician also should follow up with you and your child. Early on, there should be frequent visits while you figure out the diagnosis, as well as any other possible problems. And if medication is prescribed, frequent visits are needed initially as you figure out the best medication and dose and monitor for side effects.

    After that, the frequency of the visits will depend on how things are going, but appointments should be regular and scheduled, not just made to respond to a problem. ADHD can be a lifelong problem, bringing different challenges at different times, and it’s important that you, your child, and your doctor meet regularly so that you can best meet those challenges.

    Because together, you can.

    Watch a video of Dr. Erica Lee discussing behavioral therapies to help children with ADHD.

    About the Author

    photo of Claire McCarthy, MD

    Claire McCarthy, MD, Senior Faculty Editor, Harvard Health Publishing

    Claire McCarthy, MD, is a primary care pediatrician at Boston Children’s Hospital, and an assistant professor of pediatrics at Harvard Medical School. In addition to being a senior faculty editor for Harvard Health Publishing, Dr. McCarthy … See Full Bio View all posts by Claire McCarthy, MD Share

  • Less butter, more plant oils, longer life?

    Less butter, more plant oils, longer life?

    Bottles of all shapes and sizes filled with healthy plant oils posed on a reflective countertop

    Not such good news for butter lovers like myself: seesawing research on how healthy or unhealthy butter might be received a firm push from a recent Harvard study published in JAMA Internal Medicine. Drawing on decades of data gathered through long-term observational studies, the researchers investigated whether butter and plant oils affect mortality.

    One basic takeaway? “A higher intake of butter increases mortality risk, while a higher intake of plant-based oil will lower it,” says Yu Zhang, lead author of the study. And importantly, choosing to substitute certain plant oils for butter might help people live longer.

    What did the study find about butter versus plant oils?

    The researchers divided participants into four groups based on how much butter and plant oils they reported using on dietary questionnaires. They compared deaths among those consuming the highest amounts of butter or plant oils with those consuming the least, over a period of up to 33 years.

    Plant oils won out handily. A 15% higher risk of death was seen among those who ate the most butter compared with those who ate the least. A 16% lower risk of death was seen among those who consumed the highest amount of plant oils compared with those who consumed the least.

    Higher butter intake also raised risk for cancer deaths. And higher plant oil intake cut the risk for dying from cancer or cardiovascular disease like stroke or heart attack.

    While the study looked at five plant oils, only soybean, canola, and olive oil were linked with survival benefits. Swapping out a small amount of butter in the daily diet — about 10 grams, which is slightly less than a tablespoon — for an equivalent amount of those plant-based oils was linked with fewer total deaths and fewer cancer deaths, according to a modeling analysis.

    How could substituting plant oils for butter improve health?

    “Butter has almost no essential fatty acids and a modest amount of trans fat — the worst type of fat for cardiovascular disease,” Dr. Walter C. Willett, professor of epidemiology and nutrition at the Harvard T.H. Chan School of Public Health and professor of medicine at Harvard Medical School, noted by email.

    By contrast, the plant oils highlighted in this study are rich in antioxidants, essential fatty acids, and unsaturated fats, which research has linked to healthier levels of cholesterol and triglycerides and lower insulin resistance.

    Especially when substituted for a saturated fat like butter, plant oils also may help lower chronic inflammation within the body. Making such substitutions aligns with American Heart Association recommendations and current Dietary Guidelines for Americans for healthful eating that lower risk for chronic disease.

    And for the butter lovers? “A little butter occasionally for its flavor would not be a problem,” says Dr. Willett. “But for better health, use liquid plant oils whenever possible instead of butter for cooking and at the table.” Try sampling a variety of plant oils, like different olive oils, mustard oil, and sesame oil, to learn which ones you enjoy for different purposes, he suggests. Additionally, a blend or mix of butter with oils — or sometimes a bit of butter on its own — can satisfy taste buds.

    What about study limitations and strengths?

    The study crunched data collected through a questionnaire answered every four years by more than 221,000 adults participating in the Nurses’ Health Study, Nurses’ Health Study II, and Health Professionals Follow-Up Study. As is true of all observational studies, this type of research can’t prove cause and effect, although it adds to the body of evidence. Because most participants were white health care professionals, the findings may not apply to a wider population.

    The researchers adjusted for many variables that can affect health, including age, physical activity, smoking status, and family history of illnesses like cancer and diabetes. The size of the study, the length of follow-up, and multiple adjustments like these are all strengths.

    About the Author

    photo of Francesca Coltrera

    Francesca Coltrera, Editor, Harvard Health Blog

    Francesca Coltrera is editor of the Harvard Health Blog, and associate editor of multimedia content for Harvard Health Publishing. She is an award-winning medical writer and co-author of Living Through Breast Cancer and The Breast Cancer … See Full Bio View all posts by Francesca Coltrera

    About the Reviewer

    photo of Howard E. LeWine, MD

    Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Howard LeWine is a practicing internist at Brigham and Women’s Hospital in Boston, Chief Medical Editor at Harvard Health Publishing, and editor in chief of Harvard Men’s Health Watch. See Full Bio View all posts by Howard E. LeWine, MD Share

  • Supporting a loved one with prostate cancer: A guide for caregivers

    Supporting a loved one with prostate cancer: A guide for caregivers

    A middle-age couple having a serious conversation while sitting on the couch in their home; the husband has his hands clasped together and the wife looks sympathetic as she listens to him.

    Looking after a loved one who has prostate cancer can be overwhelming. Caregivers — usually partners, family members, or close friends — play crucial roles in supporting a patient's physical and psychological well-being. But what does that entail? You as a caregiver might not know what to say or how to help.

    "Patients diagnosed with advanced cancer are facing their own mortality," says Dr. Marc Garnick, the Gorman Brothers Professor of Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, and editor in chief of the Harvard Medical School Guide to Prostate Diseases. "And they each process that in different ways."

    Dr. Garnick emphasizes the need provide patients and families with the best information possible about the specifics of the diagnosis, symptoms, and available treatments. Some patients have near-miraculous responses to treatment, he says, even when they have very advanced cancer. "We let patients know that there are reasons to be optimistic, as treatments are improving on a regular basis," he says.

    Communication

    Dr. Garnick points out that clinicians should avoid words or phrases that can leave cancer patients feeling unempowered. A phrase like "Let's not worry about that now," for instance, is dismissive and doesn't respond to a patient's legitimate concerns. Saying "You're lucky your cancer is only stage 2" doesn't allow for the fear and anxiety a patient may have over his disease.

    Along similar lines, "It's important for caregivers to be receptive to what their loved ones are saying," Dr. Garnick says. "Instead of minimizing or questioning what your loved one is telling you, try asking 'What do you need? Tell me what you think is going to help you feel better.'"

    While it's natural to offer reassurance, you should also give your loved one space to express himself openly without offering quick solutions. Be aware that treatment can lead to emotional ups and downs, so expect mood fluctuations.

    One of the most valuable tools you have as a caregiver is the relationship you've built with your loved one over the years. During this challenging time, remind yourself of the bonds you've created together. Shared memories, inside jokes, and mutual interests can provide strength and comfort.

    Day-to-day practical support

    Managing medications can be challenging. Cancer patients can take a dozen or more pills per day on varying schedules. You can help your loved one stay on track by setting up a pill organizer (available at most drugstores) that sorts medications according to when they're needed.

    Patients with advanced prostate cancer are now being treated more often with drug combinations that include chemotherapy as well as hormonal therapies. Chemotherapy can leave patients feeling unusually cold, and patients may also get cold after experiencing hot flashes from hormonal therapy. So keep lots of blankets and warm hats on hand.

    Collaborate on a journal where you and your loved one keep health information in one place. It should contain the names and contacts of clinicians on his team, as well as details of his treatment plan. The journal can also double as a diary where you both record treatment experiences.

    You might be tasked with coordinating medical appointments. It's important to keep lists of questions you may have. Take notes so you have a record of what doctors and other people on his care team have told you. Also, you should take some time to familiarize yourself with your loved one's insurance policies or Medicare plans so you have a better understanding of what's covered.

    Don't forget to take care of yourself!

    As a caregiver, it's easy to get lost in your loved one's needs. But caring for someone with cancer while managing household responsibilities can also leave you feeling isolated, burned out, and even depressed. It's essential to also prioritize your own health and well-being.

    Make sure that you get enough sleep and exercise. Keep up with your own checkups and screening. Try to eat well, and prepare meals ahead of time to reduce stress and save time on busy days. Take breaks! Caregiving can be intense, so take time to recharge by taking a walk, reading a book, or spending time with friends.

    Here are some valuable resources that can help.

    Help for Cancer Caregivers provides support on managing feelings and emotions, keeping healthy, day-to-day needs, working together, and long-distance caregiving.

    The Prostate Cancer Foundation provides an array of educational materials, including a "caregiver's toolkit" that helps caregivers understand treatment options, side effects, and ways to be actively involved in the decision-making process.

    The Patient Advocate Foundation offers case management services to help caregivers and patients understand insurance coverage, financial assistance programs, and other resources that can reduce the financial burden of cancer treatment.

    About the Author

    photo of C.W. Schmidt

    C.W. Schmidt, Editor, Harvard Medical School Annual Report on Prostate Diseases

    C.W. Schmidt is an award-winning freelance science writer based in Portland, Maine. In addition to writing for Harvard Health Publishing, he has written for Science magazine, the Journal of the National Cancer Institute, Environmental Health Perspectives, … See Full Bio View all posts by C.W. Schmidt

    About the Reviewer

    photo of Marc B. Garnick, MD

    Marc B. Garnick, MD, Editor in Chief, Harvard Medical School Annual Report on Prostate Diseases; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Marc B. Garnick is an internationally renowned expert in medical oncology and urologic cancer. A clinical professor of medicine at Harvard Medical School, he also maintains an active clinical practice at Beth Israel Deaconess Medical … See Full Bio View all posts by Marc B. Garnick, MD Share

  • A muscle-building obsession in boys: What to know and do

    A muscle-building obsession in boys: What to know and do

    A shadowy, heavily-muscled superhero in a red cape strikes an action pose against a red and orange background; concept is body dysmorphic disorder

    By the time boys are 8 or 10, they’re steeped in Marvel action heroes with bulging, oversized muscles and rock-hard abs. By adolescence, they’re deluged with social media streams of bulked-up male bodies.

    The underlying messages about power and worth prompt many boys to worry and wonder about how to measure up. Sometimes, negative thoughts and concerns even interfere with daily life, a mental health issue known body dysmorphic disorder, or body dysmorphia. The most common form of this in boys is muscle dysmorphia.

    What is muscle dysmorphia?

    Muscle dysmorphia is marked by preoccupation with a muscular and lean physique. While the more extreme behaviors that define this disorder appear only in a small percentage of boys and young men, it may color the mindset of many more.

    Nearly a quarter of boys and young men engage in some type of muscle-building behaviors. “About 60% of young boys in the United States mention changing their diet to become more muscular,” says Dr. Gabriela Vargas, director of the Young Men’s Health website at Boston Children’s Hospital. “While that may not meet the diagnostic criteria of muscle dysmorphia disorder, it’s impacting a lot of young men.”

    “There’s a social norm that equates muscularity with masculinity,” Dr. Vargas adds. “Even Halloween costumes for 4- and 5-year-old boys now have padding for six-pack abs. There’s constant messaging that this is what their bodies should look like.”

    Does body dysmorphic disorder differ in boys and girls?

    Long believed to be the domain of girls, body dysmorphia can take the form of eating disorders such as anorexia or bulimia. Technically, muscle dysmorphia is not an eating disorder. But it is far more pervasive in males — and insidious.

    “The common notion is that body dysmorphia just affects girls and isn’t a male issue,” Dr. Vargas says. “Because of that, these unhealthy behaviors in boys often go overlooked.”

    What are the signs of body dysmorphia in boys?

    Parents may have a tough time discerning whether their son is merely being a teen or veering into dangerous territory. Dr. Vargas advises parents to look for these red flags:

    • Marked change in physical routines, such as going from working out once a day to spending hours working out every day.
    • Following regimented workouts or meals, including limiting the foods they’re eating or concentrating heavily on high-protein options.
    • Disrupting normal activities, such as spending time with friends, to work out instead.
    • Obsessively taking photos of their muscles or abdomen to track “improvement.”
    • Weighing himself multiple times a day.
    • Dressing to highlight a more muscular physique, or wearing baggier clothes to hide their physique because they don’t think it’s good enough.

    “Nearly everyone has been on a diet,” Dr. Vargas says. “The difference with this is persistence — they don’t just try it for a week and then decide it’s not for them. These boys are doing this for weeks to months, and they’re not flexible in changing their behaviors.”

    What are the health dangers of muscle dysmorphia in boys?

    Extreme behaviors can pose physical and mental health risks.

    For example, unregulated protein powders and supplements boys turn to in hopes of quickly bulking up muscles may be adulterated with stimulants or even anabolic steroids. “With that comes an increased risk of stroke, heart palpitations, high blood pressure, and liver injury,” notes Dr. Vargas.

    Some boys also attempt to gain muscle through a “bulk and cut” regimen, with periods of rapid weight gain followed by periods of extreme calorie limitation. This can affect long-term muscle and bone development and lead to irregular heartbeat and lower testosterone levels.

    “Even in a best-case scenario, eating too much protein can lead to a lot of intestinal distress, such as diarrhea, or to kidney injury, since our kidneys are not meant to filter out excessive amounts of protein,” Dr. Vargas says.

    The psychological fallout can also be dramatic. Depression and suicidal thoughts are more common in people who are malnourished, which may occur when boys drastically cut calories or neglect entire food groups. Additionally, as they try to achieve unrealistic ideals, they may constantly feel like they’re not good enough.

    How can parents encourage a healthy body image in boys?

    These tips can help:

    • Gather for family meals. Schedules can be tricky. Yet considerable research shows physical and mental health benefits flow from sitting down together for meals, including a greater likelihood of children being an appropriate weight for their body type.
    • Don’t comment on body shape or size. “It’s a lot easier said than done, but this means your own body, your child’s, or others in the community,” says Dr. Vargas.
    • Frame nutrition and exercise as meaningful for health. When you talk with your son about what you eat or your exercise routine, don’t tie hoped-for results to body shape or size.
    • Communicate openly. “If your son says he wants to exercise more or increase his protein intake, ask why — for his overall health, or a specific body ideal?”
    • Don’t buy protein supplements. It’s harder for boys to obtain them when parents won’t allow them in the house. “One alternative is to talk with your son’s primary care doctor or a dietitian, who can be a great resource on how to get protein through regular foods,” Dr. Vargas says.

    About the Author

    photo of Maureen Salamon

    Maureen Salamon, Executive Editor, Harvard Women's Health Watch

    Maureen Salamon is executive editor of Harvard Women’s Health Watch. She began her career as a newspaper reporter and later covered health and medicine for a wide variety of websites, magazines, and hospitals. Her work has … See Full Bio View all posts by Maureen Salamon

    About the Reviewer

    photo of Howard E. LeWine, MD

    Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Howard LeWine is a practicing internist at Brigham and Women’s Hospital in Boston, Chief Medical Editor at Harvard Health Publishing, and editor in chief of Harvard Men’s Health Watch. See Full Bio View all posts by Howard E. LeWine, MD Share

  • Measles is making a comeback: Can we stop it?

    Measles is making a comeback: Can we stop it?

    A road sign with the words "Measles Outbreak" in red and black against a wavy white and rusted steel background

    Has the recent news about measles outbreaks in the US surprised you? Didn’t it seem like we were done with measles?

    In the US, widespread vaccination halted the ongoing spread of measles more than 20 years ago, a major public health achievement. Before an effective vaccine was developed in the 1960s, nearly every child in the US got measles. Complications like measles-related pneumonia or hearing loss were common, and 400 to 500 people died each year.

    As I write this, there have been 1,197 confirmed cases in 34 states, mostly among children. The biggest outbreak is in west Texas, where 96 people have been hospitalized and two unvaccinated school-age children recently died, the first measles deaths in the US since 2015. Officials in New Mexico have also reported a measles-related death.

    Can we prevent these tragedies?

    Measles outbreaks are highly preventable. It’s estimated that when 95% of people in a community are vaccinated, both those individuals and others in their community are protected against measles.

    But nationally, measles vaccination rates among school-age kids fell from 95% in 2019 to 92% in 2023. Within Texas, the kindergarten vaccination rates have dipped below 95% in about half of all state counties. In the community at the center of the west Texas outbreak, the reported rate is 82%. Declining vaccination rates are common in other parts of the US, too, and that leaves many people vulnerable to measles infections.

    Only 3% of the recent cases in the US involved people known to be fully vaccinated. The rest were either unvaccinated or had unknown vaccine status (95%), or they had received only one of the two vaccine doses (2%).

    What to know about measles

    As measles outbreaks occur within more communities, it’s important to understand why this happens — and how to stop it. Here are seven things to know about measles.

    The measles virus is highly contagious

    Several communities have suffered outbreaks in recent years. The measles virus readily spreads from person to person through the air we breathe. It can linger in the air for hours after a sneeze or cough. Estimates suggest nine out of 10 nonimmune people exposed to measles will become infected. Measles is far more contagious than the flu, COVID-19, or even Ebola.

    Early diagnosis is challenging

    It usually takes seven to 14 days for symptoms to show up once a person gets infected. Common early symptoms — fever, cough, runny nose — are similar to other viral infections such as colds or flu. A few days into the illness, painless, tiny white spots in the mouth (called Koplik spots) appear. But they’re easy to miss, and are absent in many cases. A day or two later, a distinctive skin rash develops.

    Unfortunately, a person with measles is highly contagious for days before the Koplik spots or skin rash appear. Very often, others have been exposed by the time measles is diagnosed and precautions are taken.

    Measles can be serious and even fatal

    Measles is not just another cold. A host of complications can develop, including

    • brain inflammation (encephalitis), which can lead to seizures, hearing loss, or intellectual disability
    • pneumonia
    • eye inflammation (and occasionally, vision loss)
    • poor pregnancy outcomes, such as miscarriage
    • subacute sclerosing panencephalitis (SSPE), a rare and lethal disease of the brain that can develop years after the initial measles infection.

    Complications are most common among children under age 5, adults over age 20, pregnant women, and people with an impaired immune system. Measles is fatal in up to three of every 1,000 cases.

    During the latest outbreaks, 144 cases — about one in eight — have required hospitalization.

    Getting measles may suppress your immune system

    When you get sick from a viral or bacterial infection, antibodies created by your immune system will later recognize and help mount a defense against these intruders. In 2019, a study at Harvard Medical School (HMS) found that the measles virus may wipe out up to three-quarters of antibodies protecting against viruses or bacteria that a child was previously immune to — anything from strains of the flu to herpesvirus to bacteria that cause pneumonia and skin infections.

    “If your child gets the measles and then gets pneumonia two years later, you wouldn’t necessarily tie the two together. The symptoms of measles itself may be only the tip of the iceberg,” said the study’s first author, Dr. Michael Mina, who was a postdoctoral researcher in the laboratory of geneticist Stephen Elledge at HMS and Brigham and Women’s Hospital at the time of the study.

    In this video, Mina and Elledge discuss their findings.

    Vaccination is highly effective

    Two doses of the current vaccine provide 97% protection — much higher than most other vaccines.  Rarely, a person gets measles despite being fully vaccinated. When that happens, the disease tends to be milder and less likely to spread to others.

    The measles vaccine is safe

     The safety profile of the measles vaccine is excellent. Common side effects include temporary soreness in the arm, low-grade fever, and muscle pain, as is true for most vaccinations. A suggestion that measles or other vaccines cause autism has been convincingly discredited. However, this often-repeated misinformation has contributed to significant vaccine hesitancy and falling rates of vaccination.

    Ways to protect yourself from measles infection

    • Vaccination. Usually, children are given the first dose around age 1 and the second between ages 4 and 6 as part of the Measles-Mumps-Rubella (MMR) vaccine. If a child — or adult — hasn’t been vaccinated, they can have these doses later.

      If you were born after 1957 and received a measles vaccination before 1968, consider getting revaccinated or tested for measles antibodies (see below). The vaccine given before 1968 was less effective than later versions. And before 1957, most people became immune after having measles, although this immunity can wane.

    • Isolation. To limit spread, everyone diagnosed with measles and anyone who might be infected should avoid close contact with others until four days after the rash resolves.
    • Mask-wearing by people with measles can help prevent spread to others. Household members or other close contacts should also wear a mask to avoid getting it.
    • Frequent handwashing helps keep the virus from spreading.
    • Testing. If you aren’t sure about your measles vaccination history or whether you may be vulnerable to infection, consider having a blood test to find out if you’re immune to measles. Memories about past vaccinations can be unreliable, especially if decades have gone by, and immunity can wane.
    • Pre-travel planning. If you are headed to a place where measles is common, make sure you are up to date with vaccinations.

    The bottom line

    While news about measles in recent months may have been a surprise, it’s also alarming. Experts warn that the number of cases (and possibly deaths) are likely to increase. And due to falling vaccination rates, outbreaks are bound to keep occurring. One study estimates that between nine and 15 million children in the US could be susceptible to measles.

    But there’s also good news: we know that measles outbreaks can be contained and the disease itself can be eliminated. Learn how to protect yourself and your family. Engage respectfully with people who are vaccine hesitant: share what you’ve learned from reliable sources about the disease, especially about the well-established safety of vaccination.

    About the Author

    photo of Robert H. Shmerling, MD

    Robert H. Shmerling, MD, Senior Faculty Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Robert H. Shmerling is the former clinical chief of the division of rheumatology at Beth Israel Deaconess Medical Center (BIDMC), and is a current member of the corresponding faculty in medicine at Harvard Medical School. … See Full Bio View all posts by Robert H. Shmerling, MD Share

  • Counting steps is good — is combining steps and heart rate better?

    Counting steps is good — is combining steps and heart rate better?

    A round smart device with step count and heart rate in black or yellow on a red background

    Have you met your step goals today? If so, well done! Monitoring your step count can inspire you to bump up activity over time.

    But when it comes to assessing fitness or cardiovascular disease risk, counting steps might not be enough. Combining steps and average heart rate (as measured by a smart device) could be a better way for you to assess fitness and gain insights into your risk for major illnesses like heart attack or diabetes. Read on to learn how many steps you need for better health, and why tagging on heart rate matters.

    Steps alone versus steps plus heart rate

    First, how many steps should you aim for daily? There’s nothing special about the 10,000-steps number often touted: sure, it sounds impressive, and it’s a nice round number that has been linked to certain health benefits. But fewer daily steps — 4,000 to 7,000 — might be enough to help you become healthier. And taking more than 10,000 steps a day might be even better.

    Second, people walking briskly up and down hills are getting a lot more exercise than those walking slowly on flat terrain, even if they take the same number of steps.

    So, at a time when millions of people are carrying around smartphones or wearing watches that monitor physical activity and body functions, might there be a better way than just a step count to assess our fitness and risk of developing major disease?

    According to a new study, the answer is yes.

    Get out your calculator: A new measure of health risks and fitness

    Researchers publishing in the Journal of the American Heart Association found that a simple ratio that includes both heart rate and step count is better than just counting steps. It’s called the DHRPS, which stands for daily heart rate per step. To calculate it, take your average daily heart rate and divide it by your average daily step count. Yes, to determine your DHRPS you’ll need a way to continuously monitor your heart rate, such as a smartwatch or Fitbit. And you’ll need to do some simple math to arrive at your DHRPS ratio, as explained below.

    The study enrolled nearly 7,000 people (average age: 55). Each wore a Fitbit, a device that straps onto the wrist and is programmed to monitor steps taken and average heart rate each day. (Fitbits also have other features such as reminders to be active, a tracker of how far you’ve walked, and sleep quality, but these weren’t part of this study.)

    Over the five years of the study, volunteers took more than 50 billion steps. When each individual’s DHRPS was calculated and compared with their other health information, researchers found that higher scores were linked to an increased risk of

    • type 2 diabetes
    • high blood pressure (hypertension)
    • coronary atherosclerosis, heart attack, and heart failure
    • stroke.

    The DHRPS had stronger associations with these diseases than either heart rate or step count alone. In addition, people with higher DHRPS scores were less likely to report good health than those who had the lowest scores. And among the 21 study subjects who had exercise stress testing, those with the highest DHRPS scores had the lowest capacity for exercise.

    What counts as a higher score in this study?

    In this study, DHRPS scores were divided into three groups:

    • Low: 0.0081 or lower
    • Medium: higher than 0.0081 but lower than 0.0147
    • High: 0.0147 or higher.

    How to make daily heart rate per step calculations

    Here's how it works. Let’s say that over a one-month period your average daily heart rate is 80 and your average step count is 4,000. That means your DHRPS equals 80/4,000, or 0.0200. If the next month your average heart rate is still 80 but you take about 6,000 steps a day, your DHRPS is 80/6,000, or 0.0133. Since lower scores are better, this is a positive trend.

    Should you start calculating your DHRPS?

    Do the results described in this study tempt you to begin monitoring your DHRPS? You may decide to hold off until further research confirms actual health benefits from knowing that ratio.

    This study merely explored the relationship between DHRPS and risk of diabetes or cardiovascular disease like heart attack or stroke. This type of study can only establish a link between the DHRPS and disease. It can’t determine whether a higher score actually causes them.

    Here are four other limitations of this research to keep in mind:

    • Participants in this study were likely more willing to monitor their activity and health than the average person. And more than 70% of the study subjects were female and more than 80% were white. The results could have been quite different outside of a research setting and if a more diverse group had been included.
    • The findings were not compared to standard risk factors for cardiovascular disease, such as having a strong family history of cardiovascular disease or smoking cigarettes. Nor were DHRPS scores compared with standard risk calculators for cardiovascular disease. So the value of DHRPS compared with other readily available (and free) risk assessments isn’t clear.
    • The exercise stress testing findings were based on only 21 people. That’s far too few to make definitive conclusions.
    • The cost of a device to continuously monitor heart rate and steps can run in the hundreds of dollars; for many this may be prohibitive, especially since the benefits of calculating the DHRPS are unproven.

    The bottom line

    Tracking DHRPS or daily activity and other health measures might be a way to improve your health if the results prompt you to make positive changes in behavior, such as becoming more active. Or perhaps DHRPS could one day help your health care provider monitor your fitness, better assess your health risks, and recommend preventive approaches. But we don’t yet know if this new measure will actually lead to improved health because the study didn’t explore that.

    If you already have a device that continuously monitors your daily heart rate and step count, feel free to do the math! Maybe knowing your DHRPS will motivate you to do more to lower your risk of diabetes and cardiovascular disease. Or maybe it won’t. We need more research and experience with this measure to know whether it can deliver on its potential to improve health.

    About the Author

    photo of Robert H. Shmerling, MD

    Robert H. Shmerling, MD, Senior Faculty Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

    Dr. Robert H. Shmerling is the former clinical chief of the division of rheumatology at Beth Israel Deaconess Medical Center (BIDMC), and is a current member of the corresponding faculty in medicine at Harvard Medical School. … See Full Bio View all posts by Robert H. Shmerling, MD Share